| Field | Specification |
|---|---|
| Alternative names | Isorhamnetin 3-O-glucuronide |
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite — human plasma |
| Molecular weight | |
| Molecular formula | C22H20O13 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Isorhamnetin 3-glucuronide, also known as isorhamnetin 3-O-glucuronide, is described as a potent anticancer agent with anti-proliferative activity. It induces apoptosis and arrests the cell cycle at S-phase[1]. It has the molecular formula C22H20O13 (MW 492.39).
Physical & Chemical Properties
| CAS Number | 36687-76-0 |
|---|---|
| Molecular Formula | C22H20O13 |
| Molecular Weight | 492.39 g/mol |
| Structure Classification | Flavonoids Flavones |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=C(C3=CC=C(O)C(OC)=C3)OC4=CC(O)=CC(O)=C4C2=O |
| Signaling Pathway | Apoptosis |
| Initial Source | Endogenous metabolite — human plasma |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Isorhamnetin 3-glucuronide (0-100 μM; 48 h) shows dose-dependent anti-proliferative activity in MCF-7 cells[1]. Isorhamnetin 3-glucuronide (0-100 μM; 48 h) induces apoptosis and S-phase cell cycle arrest in a dose-dependent manner[1].
Cell Proliferation Assay[1]
| Cell Line | MCF-7 cells |
|---|---|
| Concentration | 0, 25, 50, 100 μM |
| Incubation Time | 48 h |
| Result | Inhibited cell proliferation in a dose-dependent manner. |
Apoptosis Analysis[1]
| Cell Line | MCF-7 cells |
|---|---|
| Concentration | 25, 100 μM |
| Incubation Time | 48 h |
| Result | Induced apoptosis with the rate of 16.8%, 49.8% at 25, 100 μM, respectively. |
Cell Cycle Analysis[1]
| Cell Line | MCF-7 cells |
|---|---|
| Concentration | 0, 50, 100 μM |
| Incubation Time | 48 h |
| Result | Induced cell cycle arrest at S-phase. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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