| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide; ISX; Isoxazole-9 |
| Cas No. | |
| Form | Tan powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (60 mg/ml): or ethanol (16 mg/ml, warm) |
| Source | Synthetic |
| Storage |
ISX9 is a small molecule known for its neurogenic properties. It promotes neurogenesis by enhancing the proliferation and differentiation of neural progenitor cells, particularly in the hippocampal subgranular zone. ISX9 induces neuronal gene expression and suppresses astrocytic phenotypes, facilitating reprogramming of glial cells toward neuronal lineages. It has been shown to improve memory and cognitive function in animal models and is being explored for its potential in regenerative therapies for neurodegenerative diseases and brain injury.
Classification: Warning
ISX9 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-628)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. JW Schneider et al. Nat. Chem. Biol. 2008 4:408
3. EM Dioum et al. Proc. Natl. Acad. Sci. U.S.A. 2011 108:20713
4. L Zhang et al. Differentiation 2011 81:233
5. RQ Ali et al. Am. J. Stem Cells 2016 5:19
6. LE Bettio et al. Neuroscience 2016 332:212
