Itraconazole

Itraconazole is a triazole antifungal agent that inhibits cytochrome P450-dependent enzymes, disrupting ergosterol synthesis in fungal membranes. Although primarily used in antifungal therapy, recent research has explored its role in inhibiting angiogenesis and hedgehog signaling pathways. While not commonly associated with neurodegenerative disease research, its emerging applications in oncology and vascular biology highlight its broader scientific relevance.

Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion

D2A Very Toxic Material Causing Other Toxic Effects - Teratogen

D2B Toxic Material Causing Other Toxic Effects - Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant

Hazard statement(s):

• H302 Harmful if swallowed.
• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.

Precautionary statement(s):

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Itraconazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-543)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).