| Field | Specification |
|---|---|
| Alternative names | Itraconazole, 84625-61-6, Sporanox, ITRAZOLE, Itraconazolum, Oriconazole, R51211, Sporanox, 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C35H38Cl2N8O4 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in chloroform (50 mg/ml) |
| SMILES | |
| InChIKey | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Itraconazole is a triazole antifungal agent that inhibits cytochrome P450-dependent enzymes, disrupting ergosterol synthesis in fungal membranes. Although primarily used in antifungal therapy, recent research has explored its role in inhibiting angiogenesis and hedgehog signaling pathways. While not commonly associated with neurodegenerative disease research, its emerging applications in oncology and vascular biology highlight its broader scientific relevance.
Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion
D2A Very Toxic Material Causing Other Toxic Effects - Teratogen
D2B Toxic Material Causing Other Toxic Effects - Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant
Hazard statement(s):
- H302 Harmful if swallowed.
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
Precautionary statement(s):
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Itraconazole (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-543)
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