| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H38O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
JH-131e-153 is a diacylglycerol (DAG)-lactone that acts as a small-molecule activator of Munc13-1, targeting its C1 domain, with an activation order of WT>I590≈R592A≈W588A. Because the Munc13-1 C1 domain is homologous in sequence and structure to that of protein kinase C (PKC), JH-131e-153 also activates PKC isoforms, with an activation order of PKCα>Munc13-1>PKCε. It regulates neuronal processes through Munc13-1 and can be used to study neurodegenerative diseases[1]. It has the molecular formula C22H38O5 and a molecular weight of 382.53 g/mol.
Physical & Chemical Properties
| CAS Number | 742104-91-2 |
|---|---|
| Molecular Formula | C22H38O5 |
| Molecular Weight | 382.53 g/mol |
| SMILES | CC(C)(C)C(OC[C@@](C/C1=C/CC(CC(C)C)CC(C)C)(CO)OC1=O)=O |
| Signaling Pathway | Epigenetics; TGF-beta/Smad |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Das J, et al. Activation of Munc13-1 by Diacylglycerol (DAG)-Lactones. Biochemistry. 2023 Aug 31.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Munc13-1 is a target of the diacylglycerol second messenger pathway and contributes to vesicle maturation during exocytosis. It takes part in neurotransmitter release by acting on synaptic vesicle initiation before vesicle fusion, and in the activity-dependent refilling of the easy-release vesicle pool (RRP).
Data provided by the manufacturer.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
