| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H24N6O |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
JH-IX-179 inhibits FLT3, with IC50 values of 4 nM against FLT3-ITD and 10 nM against FLT3-D835Y. It inhibits G1 phase arrest and induces apoptosis in FLT3-ITD-expressing cells, and it can be used in acute myeloid leukemia (AML) research[1]. It has the molecular formula C26H24N6O and a molecular weight of 436.51 g/mol.
Physical & Chemical Properties
| CAS Number | 1939104-08-1 |
|---|---|
| Molecular Formula | C26H24N6O |
| Molecular Weight | 436.51 g/mol |
| SMILES | O=C1C2=C(C(N3)=C1C4=C3C=C(C5=CNN=C5)C=C4)C=C(C6=CN(CCCN(C)C)N=C6)C=C2 |
| Signaling Pathway | Protein Tyrosine Kinase/RTK; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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