Jiyoye cell

SKU:BHC11101030
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Overview
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Jiyoye cell is a B lymphocyte cell line derived from African (Male). It is commonly used as an in vitro model for 1 research. Growth characteristics: Suspension. Supplied as cryopreserved cells with accompanying batch CoA and quality-control documentation.

Species Human
Disease model B-cell Non-Hodgkin-Lymphoma
Growth Properties Suspension
Tissue Lymphatic System
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Catalog no. Size
300366 1 cryovial
Available Options

This cell line is available in the U.S. For non-profit users, please sign and submit the Non-Profit Supply Agreement to orders@biohippo.com before placing an order. For commercial users, please complete the CLEAR Form before ordering, as additional usage fees may apply based on the intended use. For further details, please contact orders@biohippo.com. Products ship after the required agreement is completed; typical delivery is 2–3 business days. Products are shipped frozen on dry ice in cryotubes. Each cryotube typically contains 3 × 10^6 cells for adherent lines or 5 × 10^6 cells for suspension lines (refer to the batch CoA for details).

Field Specification
Mfr No 300366
Species Human
The Jiyoye cell line is an extensively studied model derived from a human Burkitt lymphoma. Burkitt lymphoma is a type of non-Hodgkin lymphoma that predominantly affects B cells, and the Jiyoye cell line retains many of the key characteristics of this malignancy. The cells exhibit the typical chromosomal translocation between the c-MYC gene and immunoglobulin gene loci, which is a hallmark of Burkitt lymphoma. This translocation leads to the overexpression of the c-MYC oncogene, driving the proliferative and aggressive nature of the tumor cells. As such, the Jiyoye cell line is an invaluable tool for studying the molecular and genetic mechanisms underlying lymphomagenesis, especially in the context of MYC-driven cancers. Jiyoye cells grow in suspension and are characterized by their high proliferation rate, which makes them suitable for a variety of experimental applications, including drug screening, gene expression studies, and apoptosis assays. The cell line is also frequently used in research focusing on Epstein-Barr virus (EBV), as Burkitt lymphoma cells, including Jiyoye, often harbor this virus, which is implicated in the pathogenesis of the disease. This makes Jiyoye particularly useful for investigating the interplay between viral oncogenes and cellular pathways in B cell malignancies. Given its origin and characteristics, the Jiyoye cell line is a critical model for oncological research, particularly in understanding the pathophysiology of B cell lymphomas.

SKU:BHC11101030

  • Antigen expression: CD10+, CD19+
  • Karyotype: 46, hypodiploid
  • cultureMedium: RPMI 1640, w: 2.0 mM stable Glutamine, w: 2.0 g/L NaHCO3 (Cytion article number 820700a)
  • supplements: Supplement the medium with 10% FBS
  • subculturing: Maintain cultures by periodically adding or replacing the medium. Initiate cultures with a density of 5 x 105 cells/ml and keep the cell concentration within the range of 3 x 105 to 1 x 106 cells/ml for optimal growth.
  • seedingDensity: 3 x 105 cells/ml
  • fluidRenewal: 2 to 3 times per week
  • postThawRecovery: Fast (48 hours)
  • freezeMedium: As a cryopreservation medium, use complete growth medium (including FBS) + 10% DMSO for adequate post-thaw viability, or CM-1 (Cytion catalog number 800100), which includes optimized osmoprotectants and metabolic stabilizers to enhance recovery and reduce cryo-induced stress.
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