| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester |
| Cas No. | |
| Form | White solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 25 mM in DMSO |
| Source | Nonomuraea longicatena |
| Storage |
K252A is a broad-spectrum protein kinase inhibitor that targets a wide range of kinases, including PKA, PKC, PKG, CaM kinase II, myosin light chain kinase (mlCK), and receptor tyrosine kinases. In neuroscience, K252A is widely used to study neurotrophic signaling, particularly through its inhibition of TrkA, the receptor for nerve growth factor (NGF). It is employed in models of neuronal differentiation, survival, and synaptic plasticity. K252A is also used to investigate the role of kinase signaling in neurodegenerative processes and to explore therapeutic strategies targeting kinase dysregulation in the brain.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
K252A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-455)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. Hashimoto Y., et al. (1991) Biochem. Biophys. Res. Comm. 181(1): 423–429.
3. Raychaudhuri S.P., Sanyal M., Weltman H., & Kundu-Raychaudhuri S. (2004) J. Invest. Derm. 122(3): 812–819.
