| Field | Specification |
|---|---|
| Alternative names | (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C26H19N3O5 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
K252B is a non-selective protein kinase inhibitor that targets CaMKII, MYLK, PKA, PKC, and cGKI by binding to the ATP-binding domain of these kinases. It is cell-permeable and used in neuroscience to study the regulation of intracellular signaling pathways involved in synaptic transmission, plasticity, and neuronal survival. K252B is particularly useful in dissecting the roles of calcium/calmodulin-dependent kinases and cyclic nucleotide-dependent kinases in neurodevelopment and neurodegeneration.
Classification: Flammable liquids (Category 4), H227
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H227 Combustible liquid
Precautionary statements:
- P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
- P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
- P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol - resistant foam for extinction.
- P403 + P235 Store in a well - ventilated place. Keep cool.
- P501 Dispose of contents/ container to an approved waste disposal plant
K252B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-456)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Teshima R., et al. (1997) J. Immun. 159(2): 964–969.
3. Knüsel B., et al. (1992) J. Neurochem. 59(2): 715–722.
