Kainic acid monohydrate

Product details

• Chemical name: (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid;hydrate.
• Also known as: Kainate
• CAS number: 58002-62-3
• Molecular formula: C10H15NO4 · H2O
• Purity: >99%
• Concentration: 0.1-10 µM.
• Form: Lyophilized Powder
• Solubility: Soluble up to 25 mM in water. Gentle warming may be required. Spin down all products before handling.
• Reconstitution: Soluble up to 25 mM in water. Gentle warming may be required. Spin down all products before handling.
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: Kainate receptors, AMPA receptors
• Source: Synthetic
• Activity: Kainic acid, a cyclic analogue of glutamic acid, is a selective agonist of the kainate receptors (EC50 = 0.6 µM - 7.4 µM, depending on subtype) 1,2, and a partial agonist at AMPA receptors (EC50 = 31 µM - 170 µM, depending on subtype) 1,3. Kainic acid has neuro-excitotoxic and epileptogenic activity in vivo4,5.
• Alternative names: Kainate

Scientific background

Kainic acid is an analog of the excitotoxic neurotransmitter glutamate used as a selective agonist of Kainate receptors1,2.Studies show that treatment with Kainic acid may induce seizures leading to neuronal death and biochemical changes similar to those seen in human patients with temporal lobe epilepsy1. Kainic acid may induce apoptotic death of rat striatal neurons in an autophagic mechanism2. Several studies of rat model show progressive death of nigral neurons following unilateral injection of Kainic acid in the striatum3.Kainate-type glutamate receptors (KARs) are highly expressed in the developing brain, where they are tonically activated to modulate synaptic transmission, network excitability and synaptogenesis4.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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