| Field | Specification |
|---|---|
| Target | |
| Alternative names | Lysine-specific demethylase 2A|CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box protein FBL7|F-box protein Lilina|F-box/LRR-repeat protein 11|JmjC domain-containing histone demethylation protein 1A|[Histone-H3]-lysine-36 demethylase 1A|KDM2A|CXXC8|FBL11|FBL7|FBXL11|JHDM1A|KIAA1004 |
| Gene ID | |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | lysine(K)-specific demethylase 2A |
| Conjugate | |
| Molecular weight | |
| Purity | |
| Purification | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Scientific Background
Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono-and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
Product Overview
This polyclonal antibody, raised in Rabbit, recognizes KDM2A. It is validated for ELISA, Western Blot, Immunohistochemistry.
Validated Applications
| Applications | ELISA, Western Blot, Immunohistochemistry |
|---|---|
| WB | 1:500 - 1:2000 |
| IHC | 1:50 - 1:200 |
Optimal dilutions should be determined by the end user for each application and sample type.
Immunogen
lysine(K)-specific demethylase 2A
Specifications
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Immunogen | lysine(K)-specific demethylase 2A |
| Purification | Immunogen Affinity Purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Form | Liquid |
| Target MW | 80-132 kDa |
| UniProt # | Q9Y2K7 |
| Gene ID | 22992 |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Alternative Names | Lysine-specific demethylase 2A|CXXC-type zinc finger protein 8|F-box and leucine-rich repeat protein 11|F-box protein FBL7|F-box protein Lilina|F-box/LRR-repeat protein 11|JmjC domain-containing histone demethylation protein 1A|[Histone-H3]-lysine-36 demethylase 1A|KDM2A|CXXC8|FBL11|FBL7|FBXL11|JHDM |
Reactivity Notes
Validated reactivity: Human, Mouse, Rat. For other species, epitope conservation may allow cross-reactivity; confirm with appropriate controls.
Safety & Handling
This product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. The formulation contains sodium azide; handle with standard laboratory precautions.
Related Products
Explore related antibodies and reagents for KDM2A research from Fine Test, or contact us for alternative formats.
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