| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (30 mg/ml) |
| Source | Synthetic |
| Storage |
KNK 437 is a small-molecule inhibitor of heat shock protein (HSP) expression, including HSP70, HSP40, and HSP105. It blocks the acquisition of thermotolerance and has been investigated in cancer therapy for its ability to sensitize cells to stress. In neuroscience, HSPs play a critical role in protein folding, aggregation prevention, and cellular stress responses. KNK 437 is used to study the role of HSPs in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, where protein misfolding and aggregation are central pathological features.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
KNK 437 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-599)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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