| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C31H33ClFN7O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
KRAS G12C inhibitor 61 inhibits phospho-ERK1/2 in MIA PaCa-2 cells, with an IC50 of 9 nM. It can be used for research on pancreatic, colorectal and lung cancers[1]. It has a molecular formula of C31H33ClFN7O2 and a molecular weight of 590.09 g/mol.
Physical & Chemical Properties
| CAS Number | 2300967-40-0 |
|---|---|
| Molecular Formula | C31H33ClFN7O2 |
| Molecular Weight | 590.09 g/mol |
| SMILES | O=C1N=C(N2[C@@H](C)CN([C@H](C)C2)C(C=C)=O)C3=C(N1C4=C(C)C=CN=C4C(C)C)N=C(C5=C(N)C=CC=C5F)C(Cl)=C3 |
| Target | K-Ras WT |
| Signaling Pathway | MAPK/ERK Pathway; Stem Cell/Wnt; GPCR/G Protein |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Brian Alan Lanman, et al. Inhibitors of kras g12c and methods of using the same. Patent. WO2019051291.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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