| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester |
| Cas No. | |
| Form | White solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml) |
| Source | Synthetic |
| Storage |
KT 5823 is a selective and reversible inhibitor of protein kinase G (PKG), derived from K-252a. In neuroscience, KT 5823 is used to study the role of PKG in neuronal signaling, synaptic plasticity, and apoptosis. It has been shown to inhibit nitric oxide-mediated signaling pathways and modulate neuroinflammatory responses. KT 5823 is a valuable tool for exploring the contribution of cyclic GMP-dependent signaling to neurodegenerative disease mechanisms.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
KT 5823 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-458)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Brunetti M., et al. (2002) Biochem. Biophys. Res. Comm. 297(3): 498–501.
3. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440.
