| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C46H51F3N8O6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
KTX-612 is an orally active PROTAC degrader of IRAK4, with a DC50 value of 7 nM, and it can be used for oncology research[1]. It has the molecular formula C46H51F3N8O6 (MW 868.94).
Physical & Chemical Properties
| CAS Number | 2573298-14-1 |
|---|---|
| Molecular Formula | C46H51F3N8O6 |
| Molecular Weight | 868.94 g/mol |
| SMILES | CC(C)(O)C1=CC2=NN(C=C2C=C1NC(C3=CC=CC(C(F)(F)F)=N3)=O)[C@H](CC4)CC[C@@H]4CN(CC5)CCC5(C6)CC6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7 |
| Target | IRAK4 |
| Signaling Pathway | PROTAC; Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
|
IRAK4 7 nM (DC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
KTX-612 is active against IRAK4, with a DC50 value of 7 nM[1].
In Vivo
KTX-612 (oral; 10 mg/kg) has an impact on oral absorption[1].
| Animal Model | Rat[1] |
|---|---|
| Dosage | 10 mg/kg |
| Administration | Oral |
| Result | Rat PO PK (10 mg/kg) KTX-612 %F 1 AUC(μM*hr) 0.060 |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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