| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C46H51F3N8O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
KTX-955 is an antitumor, effective degrader of IRAK4, with DC50 values of 5 nM for IRAK4 and 130 nM for Ikaros[1]. It has the molecular formula C46H51F3N8O7 (MW 884.94).
Physical & Chemical Properties
| CAS Number | 2573302-50-6 |
|---|---|
| Molecular Formula | C46H51F3N8O7 |
| Molecular Weight | 884.94 g/mol |
| SMILES | O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(N[C@H]4C[C@@H](C4)OC5CCN(CC5)C[C@H]6CC[C@H](N7C=C8C(C=C(C(NC(C9=CC=CC(C(F)(F)F)=N9)=O)=C8)C(C)(O)C)=N7)CC6)=C3C1=O |
| Target | IRAK4 |
| Signaling Pathway | PROTAC; Immunology/Inflammation |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
IRAK4 5 nM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Matthew Weiss. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications. Northeastern Section, ACS (NESACS).
[2]. Nello Mainolfi, et al. Irak degraders and uses thereof. WO2020264499A1
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
At 24 hours in OCI-LY10, KTX-955 (compound I-312) degrades IRAK4, with an IC50 of <0.05 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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