| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing. |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
- Also known as: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
- CAS number: 142326-59-8
- Molecular formula: C21H14CINO3
- Purity: >97%
- Concentration: 2 nM - 0.1 µM
- Form: Lyophilized Powder
- Solubility: Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.
- Reconstitution: Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NMDA receptor
- Source: Synthetic
- Activity: L-701,324 is a potent and selective NMDA receptor antagonist that acts at the glycine site1,2.
- Alternative names: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Scientific background
Glutamate is a central excitatory neurotransmitter in the nervous system and his mediating signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception. N-methyl-D-aspartate (NMDA) receptor are the major subtype of glutamate receptors that participate in synaptic transmission. NMDA receptor consists of three different subunits termed GluN1-3. Activation of NMDA receptor carried out via interaction with glycine and glutamate1.L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy) phenylquinoline-2-(H)-on) is an effective NMDA antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine binding site. It was found that L-701,324 when administered orally has an inhibitory effect on spreading depression (SD) initiations and propagation2. Moreover L-701,324 act as anticonvulsant and neuroprotective agent3. Recently it was shown that antidepressant effect of L-701,324 in mice IS mediated by elevating the hippocampal BDNF signaling cascade4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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