| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 25 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: (2S)-2-amino-4-phosphonobutanoic acid.
- Also known as: L-APB; L-(+)-2-Amino-4-phosphonobutyric acid
- CAS number: 23052-81-5
- Molecular formula: C4H10NO5P.
- Purity: >97% (HPLC)
- Concentration: 0.1-100 µM.
- Form: Lyophilized Powder
- Solubility: Up to 25 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Up to 25 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: mGluR4, 6, 7, 8
- Source: Synthetic
- Activity: L-AP4 is a group III mGluR specific agonist. Reversibly depresses basal synaptic transmission in rat hippocampal slices (IC50 = 3 µM)1.
- Alternative names: L-APB; L-(+)-2-Amino-4-phosphonobutyric acid
Scientific background
L-AP4 is a synthetic, potent and selective agonist of group III metabotropic glutamate receptors (mGluR4 and mGluR6 through mGluR8). L-AP4 also depresses basal synaptic transmission in rat hippocampal slices with an IC50 of 3 µM in a dose dependent manner. Maximum depression of 74% is obtained at a concentration of 100 µM L-AP4. A concentration of 10 µM L-AP4 induces a depression of 59% and when the mGluR antagonist MCCG is added it shows little or no effect. In contrary, the mGluR antagonists MPPG and MTPG are effective L-AP4 antagonists1.L-AP4-sensitive neuronal glutamatergic pathways include synapses of the mossy-fiber/ CA3 projection synapses of pyramidal cell projecting from the lateral olfactory tract to the pyriform cortex and synaptic contacts in the basolateral amygdala. It has also been suggested that L-AP4 sensitive receptors are important for memory and learning and might be implicated in the pathogenesis of Alzheimer's disease2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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