| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Water. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 3-Oxo-L-gulofuranolactone.
- Also known as: Vitamin C
- CAS number: 50-81-7
- Molecular formula: C6H8O6.
- Purity: >98%
- Concentration: 10 nM - 5 µM.
- Form: Lyophilized Powder
- Solubility: Water. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Water. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: T-type Ca2+ channels
- Source: Synthetic
- Activity: IC50 of 6.5 µM on T-type current of rat DRG neurons1. IC50s of 10 and 25 nM on cloned CaV3.2 channels from human and rat, respectively1.
- Alternative names: Vitamin C
Scientific background
The T-type calcium channel belongs to the voltage-gated Ca2+ channel (CaV) family. "T" stands for transient, referring to the length of activation. As with other sub-types of voltage-gated Ca2+ channels, the α1 subunit is the one that determines most of the channel's properties. T-type calcium channels may contain one of three α1 subunits, α1G (CaV3.1), α1H (CaV3.2) or α1I (CaV3.3)1-3.T-type Ca2+ channels are involved in the control of neuronal excitability and their gating can be modulated by a variety of redox agents4.L-Ascorbic acid (ascorbate) is an endogenous redox agent that selectively inhibits native CaV3.2 channels in the peripheral and central neurons4.L-Ascorbic acid has an IC50 of 6.5 µM on T-type current of rat DRG neurons, and IC50s of 10 and 25 nM on cloned CaV3.2 channels from human and rat, respectively4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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