| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (a-S)-a-Carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium inner salt; 2-Mercaptohistidine betaine; NSC-7175 |
| Cas No. | |
| Form | White to off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in water (50 mg/ml) |
| Source | Synthetic |
| Storage |
L-Ergothioneine is a naturally occurring antioxidant found in high concentrations in various tissues, including the brain. It protects neuronal cells from β-amyloid-induced apoptosis and mitigates cisplatin-induced neurotoxicity, suggesting a role in neuroprotection. Additionally, it enhances cognitive performance in animal models and interferes with endothelial cell senescence, indicating potential benefits in age-related neurodegenerative conditions. Its ability to cross the blood-brain barrier and accumulate in neural tissues supports its relevance in neuroscience and neurodegenerative disease research.
Classification: Warning, Irritant GHS Hazard Statements
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes:
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305
L-Ergothioneine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-634)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. JH Jang et al. Free Radic. Biol. Med. 2004 36:288
3. TY Song et al. Food Chem. Toxicol. 2010 48:3492
4. N D’Onofrio et al. Free Radic. Biol. Med. 2016 96:211
