| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
| Cas No. | |
| Form | Yellow crystalline solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Solubility in water is 0.007 mg/ml and in 0.1N HCl is 0.001 mg/ml at 25° C |
| Source | Synthetic |
| Storage |
Lapatinib is a dual tyrosine kinase inhibitor that targets the ErbB2 (HER2) and epidermal growth factor receptor (EGFR) pathways. While primarily used in oncology, Lapatinib has potential applications in neuroscience due to the involvement of EGFR signaling in neuroinflammation, gliosis, and neurodegeneration. It is being explored for its ability to modulate glial cell activity and protect against excitotoxicity in models of Alzheimer's disease and brain injury. Lapatinib’s ability to cross the blood-brain barrier enhances its utility in central nervous system research.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Lapatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-459)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Dahal B.K., et al. (2010) Am. J. Resp. Critical Care Med. 181(2): 158–167.
