| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C29H31ClN6O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
LB-60-OF61 hydrochloride is a potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase). It is a cytotoxic compound with selectivity toward MYC-overexpressing cell lines[1]. It has the molecular formula C29H31ClN6O2 and a molecular weight of 531.05 g/mol.
Physical & Chemical Properties
| CAS Number | 742064-38-6 |
|---|---|
| Molecular Formula | C29H31ClN6O2 |
| Molecular Weight | 531.05 g/mol |
| SMILES | O=C(NCC1=CC=CN=C1)C2=CC=C(OCC3=CC4=CN=C(C#N)N=C4N3CCC5CCCCC5)C=C2.[H]Cl |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In a 384 well format, LB-60-OF61 shows potency against HCT116 cells, with an IC50 of about 30 nM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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