| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444 |
| Cas No. | |
| Form | Yellow Powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 20 mg/ml DMSO |
| Source | Synthetic |
| Storage |
LDN-57444 inhibits ubiquitin C-terminal hydrolase UCH-L1, decreasing proteasome activity and increasing levels of ubiquitinated proteins. It induces apoptosis and alters synaptic protein distribution and spine morphology. This compound is widely used in neuroscience to study synaptic plasticity, neurodegenerative disease progression, and protein homeostasis.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
- H302 – Harmful if swallowed
- H317 – May cause an allergic skin reaction
Precautionary Statements:
P280 – Wear protective gloves.
LDN-57444 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-332)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109.
3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.
