| Field | Specification |
|---|---|
| Alternative names | 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C12H9F3N2O2 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | May be dissolved in DMSO (30 mg/ml); or Ethanol (27 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | White crystalline solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Leflunomide is an immunomodulatory agent that inhibits dihydroorotate dehydrogenase, thereby suppressing pyrimidine synthesis and T-cell proliferation. In neuroscience, leflunomide is explored for its anti-inflammatory properties, particularly in models of neuroinflammation and autoimmune neurological disorders such as multiple sclerosis. By modulating immune responses, leflunomide helps elucidate the role of peripheral and central immune mechanisms in neurodegenerative disease progression. Its application in neuroimmunology research supports the development of therapeutic strategies targeting immune-mediated neuronal damage.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R25 – Toxic if swallowed
- R62 – Possible risk of impaired fertility
- R63 – Possible risk of harm to the unborn child
Hazard Phrases:
- H301 – Toxic if swallowed.
- H315 – Causes skin irritation.
- H319 – Causes serious eye irritation
- H335 – May cause respiratory irritation
Precautionary Phrases:
- P264 – Wash hands thoroughly after handling
- P280 – Wear protective gloves/protective clothing/eye protection/ face protection
- P301+310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
- P308+313 - If exposed or concerned: Get medical advice/attention
Leflunomide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-368)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Smolen JS., Emery P. (2000) Rheumatology. 39: 48-56.
3. Fox R.I., Herrman M.L., Franqou C.G., Wahl G.M., Morns R.E., Strand V. and Kirschbaum B.S. (1999) Clin Immunol 93(3): 198-208.
