| Field | Specification |
|---|---|
| Alternative names | LDK |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H14N4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Lenaldekar, also known as LDK, inhibits both human and murine T-cell expansion and autoimmune T-cell responses, and it also induces cancer cell apoptosis. It can be used in research on T-cell-mediated autoimmune diseases[1][2]. It has a molecular formula of C18H14N4 and a molecular weight of 286.33 g/mol.
Physical & Chemical Properties
| CAS Number | 418800-15-4 |
|---|---|
| Molecular Formula | C18H14N4 |
| Molecular Weight | 286.33 g/mol |
| SMILES | C1(/C=N/NC2=C3N=CC=CC3=CC=C2)=CNC4=C1C=CC=C4 |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Over 4 days, Lenaldekar inhibits CD3+ T cell proliferation in a dose-dependent manner, with an IC50 of 3 μM[1]. A memory T cell response to influenza antigen H3 is reduced by Lenaldekar (3 μM, 4 days)[1]. In Jurkat T-ALL cells, Lenaldekar (48 h) is cytotoxic, with IC50s of 0.8 μM, and it induces apoptosis (1 μM)[2].
In Vivo
In mice sensitized with the encephalitogenic PLP139-151 peptide, Lenaldekar (40 mg/kg per day, i.p.) inhibits relapse of experimental autoimmune encephalomyelitis (EAE)[1]. Lenaldekar (16 mg/kg, i.p., twice daily) inhibits tumor progression in a mouse xenograft model of T-cell acute lymphoblastic leukemia (T-ALL)[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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