| Field | Specification |
|---|---|
| Target | |
| Alternative names | CDZ173 phosphate |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C21H28F3N6O6P |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Leniolisib phosphate, also known as CDZ173 phosphate, is a potent, selective PI3Kδ inhibitor with potential for the treatment of immunodeficiency disorders. It is supplied as a white to off-white solid (C21H28F3N6O6P, MW 548.45) at 98.88% purity.
Physical & Chemical Properties
| CAS Number | 1354691-97-6 |
|---|---|
| Molecular Formula | C21H28F3N6O6P |
| Molecular Weight | 548.45 g/mol |
| Purity | 98.88% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CCC(N1C[C@H](CC1)NC2=C3CN(CCC3=NC=N2)C4=CC(C(F)(F)F)=C(N=C4)OC)=O.O=P(O)(O)O |
| Target | PI3Kδ, PI3Kα, PI3Kβ, PI3Kγ, DNA-PK |
| Signaling Pathway | PI3K/Akt/mTOR |
| Solubility | In Vitro: H2O: 100 mg/mL (182.33 mM; Requires sonication) DMSO: 100 mg/mL (182.33 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
PI3Kδ 11 nM (IC50) |
PI3Kα 280 nM (IC50) |
PI3Kβ 480 nM (IC50) |
PI3Kγ 2.57 nM (IC50) |
DNA-PK 880 nM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 100 mg/mL (182.33 mM) | requires sonication |
| DMSO | 100 mg/mL (182.33 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
In cell lines and patient-derived lymphocytes expressing the APDS mutant p110δ, pathway activity increases, as measured by phosphorylation of AKT or S6, and Leniolisib phosphate suppresses this increase in a concentration-dependent manner[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics. Mol Syst Biol 2024 Jan;20(1):28-55. PMID: 38177929
