| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Elactocin, LMB, Mantuamycin, NSC 364372 |
| Cas No. | |
| Form | Solution in ethanol (1 mg/ml) |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved into DMSO or ethanol. Use solutions made with DMSO within 24 hours. |
| Source | Synthetic |
| Storage |
Leptomycin B is a potent inhibitor of nuclear export proteins, specifically targeting CRM1/exportin 1. By blocking the nuclear export of tumor suppressors and regulatory proteins, it has been studied extensively in cancer research. In neuroscience, its ability to modulate nuclear-cytoplasmic transport has implications for neurodegenerative diseases where protein mislocalization contributes to pathology. Leptomycin B serves as a valuable tool in understanding nucleocytoplasmic dynamics in neuronal cells.
Classification: B2 Flammable liquid - Flammable liquid
D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion, Toxic by skin absorption
Hazard statement(s):
- H225 Highly flammable liquid and vapour.
- H301 + H311 Toxic if swallowed or in contact with skin
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H331 Toxic if inhaled.
- H370 Causes damage to organs.
Precautionary statement(s):
- P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
- P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
- P280 Wear protective gloves/ protective clothing.
- P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician.
Leptomycin B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-534)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
