| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | KT5555, CEP-701, (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Source | Synthetic |
| Storage |
Lestaurtinib is a potent inhibitor of JAK2, FLT3, and TrkA receptor tyrosine kinases. In neuroscience, it is used to study neurotrophic signaling and inflammatory pathways. By inhibiting TrkA, Lestaurtinib helps elucidate the role of nerve growth factor (NGF) signaling in neuronal survival and differentiation. Its inhibition of JAK2 also makes it relevant in models of neuroinflammation and cytokine signaling. Lestaurtinib is a valuable compound for investigating kinase-driven mechanisms in neurodegenerative diseases.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Lestaurtinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-460)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Hexner E.O., et al. (2008) Blood. 111(12): 5663–5671.
