| Field | Specification |
|---|---|
| Target | |
| Alternative names | LGI1, Leucine-rich glioma-inactivated protein 1, Epitempin 1, EPT, ETL1, ADLTE, ADPEAF, ADPAEF, IB1099, OTTHUMP00000020121, OTTHUMP00000020122 |
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| Immunogen | Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4. |
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LGI1 (Leucine-Rich Glioma Inactivated 1) is a secreted synaptic protein that modulates neuronal excitability and synaptic transmission. It interacts with ADAM22 and ADAM23 to stabilize AMPA receptor function and maintain synaptic integrity. Mutations in LGI1 are linked to autosomal dominant lateral temporal lobe epilepsy (ADTLE) and have been implicated in autoimmune encephalitis. In neurodegenerative disease research, LGI1 is gaining attention for its role in synaptic maintenance, neuroinflammation, and neuronal survival. Dysregulation of LGI1 may contribute to cognitive decline and seizure susceptibility. Its dual role in epilepsy and neurodegeneration highlights LGI1 as a valuable biomarker and therapeutic target in synaptic pathologies.
1 µg/ml of SMC-461 was sufficient for detection of LGI1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-461D — Size: 100 ug: LGI1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D, RRID: AB_2702009)
- SMC-461D-A390 — Size: 100 ug: LGI1 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-A390, RRID: AB_2702010)
- SMC-461D-A488 — Size: 100 ug: LGI1 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-A488, RRID: AB_2702011)
- SMC-461D-A594 — Size: 100 ug: LGI1 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-A594, RRID: AB_2702013)
- SMC-461D-APC — Size: 100 ug: LGI1 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-APC, RRID: AB_2702019)
- SMC-461D-BI — Size: 100 ug: LGI1 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-BI, RRID: AB_2702020)
- SMC-461D-FITC — Size: 100 ug: LGI1 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-FITC, RRID: AB_2702021)
- SMC-461D-HRP — Size: 100 ug: LGI1 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-HRP, RRID: AB_2702022)
- SMC-461D-PCP — Size: 100 ug: LGI1 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-PCP, RRID: AB_2702024)
- SMC-461D-RPE — Size: 100 ug: LGI1 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461D-RPE, RRID: AB_2702025)
- SMC-461S — Size: 12 ug: LGI1 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-461S, RRID: AB_2702009)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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3. Gu W., et al. (2005) Mol. Biol. Evol. 22:2209-16.
4. Fukata Y., et al. (2006) Science. 313:1792-5.
