| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | LH846, LH-846, N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide |
| Cas No. | |
| Form | White to beige powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
LH 846 is a selective inhibitor of Casein Kinase 1 delta (CK1δ), a key regulator of circadian rhythm and PER1 protein stability. CK1δ has been implicated in neurodegenerative diseases such as Alzheimer’s, where circadian disruption and abnormal protein phosphorylation are common. By modulating CK1δ activity, LH 846 offers a valuable tool for exploring the links between circadian regulation, neurodegeneration, and cognitive decline.
Classification: Acute toxicity, Oral (Category 4)
Chronic aquatic toxicity(Category 4)
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302 Harmful if swallowed.
- H413 May cause long lasting harmful effects to aquatic life.
LH 846 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-503)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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