| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-Phenyl-3,3-bis(pyridine-4-ylmethyl)indolin-2-one, dihydrochloride; DuP996 |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (25 mg/ml): or water (25 mg/ml) |
| Source | Synthetic |
| Storage |
Linopirdine dihydrochloride is a cognitive enhancer that increases acetylcholine release by blocking Kv7 (KCNQ) voltage-gated potassium channels. This blockade enhances neuronal excitability and synaptic transmission, leading to improved performance in learning and memory tasks in animal models. Its state-dependent channel inhibition favors activated subunits, making it a targeted modulator of neuronal signaling. Linopirdine has been studied for its potential in treating cognitive deficits associated with Alzheimer’s disease and other neurodegenerative conditions.
Classification: Warning
Linopirdine dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-629)
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2. HS Wang et al. Science 1998 282:1890
3. DJ Fontana et al. Pharmacol. Biochem. Behav. 1994 49:1075
4. DL Greene et al. J. Pharmacol. Exp. Ther. 2017 362:177
