| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride.
- CAS number: 113168-57-3
- Molecular formula: C26H23Cl2N3O.
- Purity: >98%
- Concentration: 0.1-300 µM.
- Form: Lyophilized powder.
- Solubility: 100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
- Reconstitution: 100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KCNQ K+ channels
- Source: Synthetic
- Activity: Linopirdine blocks KCNQ channels with an IC50 of 2.4 μM for KV7.2/3 heteromers1.
Scientific background
KCNQ2 (KV7.2) and KCNQ3 (KV7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current1. Linopirdine, a putative cognition enhancing drug, increases acetylcholine (ACh) release in rat brain tissue and improves performance in animal models of learning and memory. In addition to ACh, Linopirdine has been shown to enhance the in vitro release of dopamine and 5-hydroxytryptamine (5-HT), and, to a lesser extent, γ-aminobutyric acid and glutamate2. The enhanced release of one or more neurotransmitters may account for the activity linopirdine displays in behavioral models of learning and memory3. The mechanism whereby linopirdine enhances acetylcholine release has been proposed to involve inhibition of the M-type K+ current (IM). Linopirdine is selective for IM with an IC50 value of 2.4 μM2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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