| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C44H87NO5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Lipid M, which has a pKa of 6.75, can be used to deliver mRNA vaccines and elicit a robust immune response with improved tolerability[1]. It has the molecular formula C44H87NO5 and a molecular weight of 710.17 g/mol.
Physical & Chemical Properties
| CAS Number | 2089251-57-8 |
|---|---|
| Molecular Formula | C44H87NO5 |
| Molecular Weight | 710.17 g/mol |
| SMILES | OCCN(CCCCCCCOC(C(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
In CD-1 mice, rapid clearance in muscle, spleen and liver follows i.m. administration of Lipid M (50 μL of LNP-formulated luciferase mRNA containing 2 μg)[1]. In cynomolgus monkeys, i.m. administration of Lipid M (300 μL of LNP-formulated IgG mRNA containing 500 μg) produces serum antibody expression comparable with that obtained from MC3-based LNPs[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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