| Field | Specification |
|---|---|
| Target | |
| Alternative names | Lon protease homolog, mitochondrial|LONHs|Lon protease-like protein (LONP)|Mitochondrial ATP-dependent protease Lon|Serine protease 15|LONP1|PRSS15 |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | lon peptidase 1, mitochondrial |
| Conjugate | |
| Molecular weight | |
| Purity | |
| Purification | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Scientific Background
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory(StAR) protein.
Product Overview
This monoclonal antibody (clone 9H10), raised in Mouse, recognizes LONP1. It is validated for ELISA, Western Blot, Immunohistochemistry, Immunofluorescence.
Validated Applications
| Applications | ELISA, Western Blot, Immunohistochemistry, Immunofluorescence |
|---|---|
| WB | 1:500-1:10000 |
| IHC | 1:400-1:1600 |
| IF | 1:10-1:100 |
Optimal dilutions should be determined by the end user for each application and sample type.
Immunogen
lon peptidase 1, mitochondrial
Specifications
| Host | Mouse |
|---|---|
| Clonality | Monoclonal |
| Clone | 9H10 |
| Isotype | IgG2a |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Immunogen | lon peptidase 1, mitochondrial |
| Purification | Protein A+G Purification |
| Purity | ≥95% as determined by SDS-PAGE |
| Form | Liquid |
| Target MW | 100 kDa |
| UniProt # | P36776 |
| Gene ID | 9361 |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Alternative Names | Lon protease homolog, mitochondrial|LONHs|Lon protease-like protein (LONP)|Mitochondrial ATP-dependent protease Lon|Serine protease 15|LONP1|PRSS15 |
Reactivity Notes
Validated reactivity: Human, Mouse, Rat. For other species, epitope conservation may allow cross-reactivity; confirm with appropriate controls.
Safety & Handling
This product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. The formulation contains sodium azide; handle with standard laboratory precautions.
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Explore related antibodies and reagents for LONP1 research from Fine Test, or contact us for alternative formats.
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