| Field | Specification |
|---|---|
| Target | |
| Alternative names | LRP4, LRP-4, LRP10, MEGF7, Low density lipoprotein receptor related protein 4, Multiple epidermal growth factor like domains 7, LDLR dan, LDLR, KIAA0816, Corin |
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| Reactivity | |
| Applications | |
| Immunogen | Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4 |
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LRP4 (Low-Density Lipoprotein Receptor-Related Protein 4) is a transmembrane receptor essential for neuromuscular junction formation and synaptic signaling. It acts as a co-receptor for agrin and MuSK, facilitating synapse development and maintenance. In the central nervous system, LRP4 influences astrocyte-neuron communication and synaptic plasticity. Mutations or autoantibodies targeting LRP4 are linked to myasthenia gravis and may contribute to cognitive dysfunction. Emerging evidence suggests LRP4 plays a role in neurodegenerative diseases by modulating synaptic integrity and glial function. Its involvement in both peripheral and central synaptic regulation positions LRP4 as a promising target for therapeutic intervention in neuromuscular and neurodegenerative disorders.
1 µg/ml of SMC-418 was sufficient for detection of LRP4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-418D — Size: 100 ug: LRP4 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D, RRID: AB_2701271)
- SMC-418D-A390 — Size: 100 ug: LRP4 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-A390, RRID: AB_2701272)
- SMC-418D-A488 — Size: 100 ug: LRP4 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-A488, RRID: AB_2701273)
- SMC-418D-A594 — Size: 100 ug: LRP4 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-A594, RRID: AB_2701275)
- SMC-418D-APC — Size: 100 ug: LRP4 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-APC, RRID: AB_2701281)
- SMC-418D-BI — Size: 100 ug: LRP4 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-BI, RRID: AB_2701282)
- SMC-418D-FITC — Size: 100 ug: LRP4 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-FITC, RRID: AB_2701283)
- SMC-418D-HRP — Size: 100 ug: LRP4 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-HRP, RRID: AB_2701284)
- SMC-418D-PCP — Size: 100 ug: LRP4 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-PCP, RRID: AB_2701286)
- SMC-418D-RPE — Size: 100 ug: LRP4 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418D-RPE, RRID: AB_2701287)
- SMC-418S — Size: 12 ug: LRP4 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-418S, RRID: AB_2701271)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
