LY 456236 hydrochloride

Product details

• Chemical name: 6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine hydrochloride.
• Also known as: MPMQ hydrochloride
• CAS number: 338736-46-2
• Molecular formula: C16H16ClN3O2.
• Purity: >98% (HPLC)
• Concentration: 100 nM - 10 µM.
• Form: Lyophilized powder.
• Solubility: Up to 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: mGluR1
• Source: Synthetic
• Activity: LY 456236 hydrochloride is an antagonist of mGluR1, selective over mGluR5 receptors (IC50 values of 143 nM and >10 μM, respectively)1.
• Alternative names: MPMQ hydrochloride

Scientific background

LY 456236 hydrochloride is a potent and selective antagonist of mGluR1 receptors with an IC50 value of 140 + 5 nM2.Several studies in rat and mouse models have shown that systemic administration of LY 456236 reduces hyperalgesia induced by formalin and mechanical allodynia following spinal nerve ligation. In the anxiety models tested, LY 456236 produces anxiolytic-like effects1. Another study shows that LY456236 may have clinical value in the treatment of epilepsy and other seizure disorders2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCR) and play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found in somatodendritic domains and postsynaptically regulate neuronal excitability and synaptic transmission through several intracellular second messenger systems3,4.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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