| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Source | Synthetic |
| Molecular formula | C17H22N4O. |
| Purity | |
| Activity | |
| Reconstitution | |
| Solubility | 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Concentration | |
| Form | Lyophilized powder. |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product details
- Chemical name: 1-methyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]indazole-3-carboxamide.
- PubChem CID: 3970
- Molecular formula: C17H22N4O.
- Purity: >97%
- Concentration: 1 nM - 1 µM.
- Form: Lyophilized powder.
- Solubility: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-HT3 receptors
- Source: Synthetic
- Activity: LY278584 is a specifiic 5-HT3 antagonist. 0.1 μM completely blocks 1 μM 5HT evoked current in Xenopus oocytes1.
Scientific background
LY278584 is a potent and selective antagonist of 5-HT3 receptors. Its structure is very similar to granisetron, also a 5-HT3 receptor antagonist. LY278584 is a useful ligand for studying the localization of 5-HT3 receptors in rat brain1,2.Numerous studies have shown that 5-HT3 antagonism is able to modulate mesolimbic dopaminergic activity in rodents. There is evidence that blockade of 5-HT3 receptors may be involved in nociception. Another study conducted on 5-HT3 antagonism showed that LY278584 significantly inhibits high frequency electroacupuncture antinociception in early stages3.The 5-HT3 receptors mediate the action of serotonin in the body. These receptors are members of the Cys-loop ligand-gated cation channels, which are expressed throughout the central and peripheral nervous systems and mediate a variety of physiological functions such as emotion, cognition, memory, pain perception, and gastrointestinal functions including secretion and motility4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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