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Compound Overview
LY303511 hydrochloride (CAS 854127-90-5) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 854127-90-5 |
|---|---|
| Molecular Formula | C19H20Cl2N2O2 |
| Molecular Weight | 379.28 g/mol |
| SMILES | Cl.Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
sonication can accelerate dissolution. If the compound is not dissolving, sonication is recommended. If you don't have an ultrasound machine, a lower solvent concentration or using less powder are recommended.
If you are using DMSO for preparation,sterilization is not recommended, as DMSO itself possesses strong sterilizing properties. The prepared solution is sterile. For further assurance, it can be left overnight at 4°C. The safest method is to filter through a specialized organic filter membrane. If water is used for preparation,sterilization can be achieved by filtering through a 0.22 μm filter membrane.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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