LY364947

LY364947 is a potent and selective inhibitor of TGF-β type I receptor kinase, blocking downstream SMAD signaling. TGF-β signaling is involved in neuroinflammation, synaptic plasticity, and glial activation—processes central to neurodegenerative disease progression. LY364947 has been used to investigate the role of TGF-β in central nervous system disorders, offering insights into therapeutic strategies targeting neuroinflammatory pathways.

Classification: Acute toxicity, Oral (Category 3), H301

Skin irritation (Category 2), H315

Eye irritation (Category 2A), H319

Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Acute aquatic toxicity (Category 1), H400

Chronic aquatic toxicity (Category 1), H410

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H301 Toxic if swallowed.
• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.
• H410 Very toxic to aquatic life with long lasting effects.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P271 Use only outdoors or in a well-ventilated area.
• P273 Avoid release to the environment.
• P280 Wear protective gloves/ eye protection/ face protection.
• P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
• P321 Specific treatment (see supplemental first aid instructions on this label).
• P330 Rinse mouth.
• P332 + P313 If skin irritation occurs: Get medical advice/ attention.
• P337 + P313 If eye irritation persists: Get medical advice/ attention.
• P362 Take off contaminated clothing and wash before reuse.
• P391 Collect spillage.
• P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
• P405 Store locked up.
• P501 Dispose of contents/ container to an approved waste disposal plant.

LY364947 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-504)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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