| Field | Specification |
|---|---|
| Alternative names | LTNAM |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C24H31N5O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Lys-psi(CH2NH)-Trp(Nps)-OMe, also known as LTNAM, is a lysine-tryptophan (Nps) pseudodipeptide analog formed by replacing the peptide bond of the Lys-Trp(Nps) molecule with an aminomethylene bond, giving it analgesic activity. After intracerebroventricular administration in mice, it produces analgesia that is dose-dependent, reversible by naloxone, and longer-lasting than that of the parent compound. In rat striatal slices, it shields methionine enkephalin from degradation and binds low-dose opioid peptides to generate analgesia, and it also blocks brain aminopeptidase activity in both in vitro and in vivo settings. Its greater resistance to proteolysis compared with the parent pseudodipeptide may account for this prolonged analgesic effect. It has the molecular formula C24H31N5O4S and a molecular weight of 485.60 g/mol.
Physical & Chemical Properties
| CAS Number | 141365-20-0 |
|---|---|
| Molecular Formula | C24H31N5O4S |
| Molecular Weight | 485.60 g/mol |
| SMILES | O=C(OC)[C@@H](NC[C@@H](N)CCCCN)CC1=C(SC2=CC=CC=C2[N+]([O-])=O)NC3=C1C=CC=C3 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Prolonged antinociceptive activity of pseudodipeptide analogues of Lys-Trp(Nps) and Trp(Nps)-Lys
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
