Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)

SKU:BHB20425897
Overview
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Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) (CAS 1234494-75-7) is a small molecule inhibitor supplied as a solid powder by TargetMol. For biochemical profiling and cell-based assay applications.
Activity Small Molecule Inhibitor
CAS No. 1234494-75-7
Molecular Weight 474.34 g/mol
Form Solid
Shipping Room Temperature
Options selector
Catalog no. Size
T36627-1MG 1 mg
T36627-5MG 5 mg
T36627-10MG 10 mg
Available Options

Select the variant that best fits your experiment. Availability and lead time may vary by option.

  • Options: Size: 1 mg, 5 mg, 10 mg
  • Lead time: In Stock at Manufacturer — options listed in "Availability Content"; other statuses may take longer.
  • Storage: −20 °C
  • Shipping: Room temperature (RT) shipment.
  • Upon receipt: Store at −20 °C as soon as possible.
  • Sales terms and conditions: Please review prior to ordering.
Field Specification
Mfr No T36627
Activity
  • Small Molecule Inhibitor
Cas No. 1234494-75-7
Molecular Weight 474.34
Product Type
  • Small Molecule Inhibitor
Signaling Pathway Others
SMILES Cl.Cl.Cl.Cl.(6)-(7)(6)(-(7)-(6))=(7)(6)-(6)-(6)-(7)-(6)-(6)-(6)-(7)-(6)-(6)-(6)(7)=(6)(/(7)-(6))-(7)-(6)
Target Others

Compound Overview

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) (CAS 1234494-75-7) is a research-grade small molecule supplied by TargetMol.

Physical Properties

CAS Number 1234494-75-7
Molecular Formula C15H40Cl4N8
Molecular Weight 474.34 g/mol
SMILES Cl.Cl.Cl.Cl.(6)-(7)(6)(-(7)-(6))=(7)(6)-(6)-(6)-(7)-(6)-(6)-(6)-(7)-(6…
Form Solid
Shipping Room Temperature (RT)

Biological Activity

Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 uM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.

Safety & Regulatory

For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.

Can high-temperature sterilization be used for inhibitors?

Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.

If the product does not dissolve even when it is below the maximum solubility stated in the instructions, what should I do?

Try the following steps: (1) warm the DMSO solvent to 37–50 °C before adding the compound; (2) vortex vigorously for 30 seconds then bath-sonicate for 1–2 minutes; (3) if still undissolved, prepare a more dilute stock. Note that maximum solubility values are reference conditions — actual solubility can vary with temperature, solvent lot, and compound batch. Contact BioHippo support if dissolution problems persist.

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

  • Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
  • Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
  • Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
  • QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
  • Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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