| Field | Specification |
|---|---|
| Alternative names | Lys-Thr |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C10H21N3O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Lysyl threonine (Lys-Thr) is a dipeptide that can be used to synthesize the pentapeptide Gly-Thr-Gly-Lys-Thr, which confers cell sensitivity to anticancer agents by inhibiting the binding of CAGE to GSK3β and reducing CyclinD1 expression[1]. It is supplied as a white to light yellow solid (C10H21N3O4, MW 247.29) at 98.76% purity.
Physical & Chemical Properties
| CAS Number | 97791-84-9 |
|---|---|
| Molecular Formula | C10H21N3O4 |
| Molecular Weight | 247.29 g/mol |
| Purity | 98.76% |
| Appearance | Solid |
| Color | White to light yellow |
| Sequence | Lys-Thr |
| Sequence (one-letter) | KT |
| SMILES | C[C@H]([C@H](NC([C@@H](N)CCCCN)=O)C(O)=O)O |
| Solubility | In Vitro: DMSO: 100 mg/mL (404.38 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Sealed storage, away from moisture. Powder: -80°C, 2 years; -20°C, 1 year. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Kim Y, et al. The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3β and decreasing the expression of cyclinD1. Oncotarget. 2017 Feb 21;8(8):13632-13651.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (404.38 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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