| Field | Specification |
|---|---|
| Alternative names | L-Lysyl-L-lysine |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C12H26N4O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Lysyllysine, also known as L-Lysyl-L-lysine, is an orally active substrate of PepT1. In neonatal piglets with PN-induced intestinal atrophy, it enhances whole-body protein synthesis, improves intestinal structure, alleviates intestinal mucosal inflammation, and shows higher lysine bioavailability. It also inhibits the growth of axenic cyanobacterial strains and induces their cell lysis, and can be used in studies of intestinal atrophy and metabolism[1][2]. It has a molecular formula of C12H26N4O3 and a molecular weight of 274.36 g/mol.
Physical & Chemical Properties
| CAS Number | 13184-13-9 |
|---|---|
| Molecular Formula | C12H26N4O3 |
| Molecular Weight | 274.36 g/mol |
| SMILES | NCCCC[C@H](NC([C@@H](N)CCCCN)=O)C(O)=O |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In axenic Microcystis novacekii TAC 20-1 cultures and axenic Microcystis viridis NIES 102 cultures, Lysyllysine blocks growth and induces cell lysis, though its inhibitory activity is lower than that of the L-lysine monomer[2].
In Vivo
In neonatal piglets with PN-induced intestinal atrophy, Lysyllysine (lysyl-lysine, Lys-Lys) (0.50 g/kg/d; enteral delivery; continuous administration; 18 h) raises whole-body protein synthesis by 38% compared with equimolar free lysine given orally, while improving intestinal morphology, easing mucosal inflammation and reinforcing intestinal barrier function by way of PepT1-mediated absorption[1].
| Animal Model | Yucatan miniature piglets (male, 7-8 days old, initial body weight 1.69 kg)[1] |
|---|---|
| Dosage | 0.50 g/kg/d |
| Administration | enteral; continuous; 18 hours |
| Result | Attained superior intestinal morphological indicators including jejunal mucosa weight 71 mg/cm, villus height 279 μm and small intestinal length 251 cm/kg body weight compared with the other two groups. Achieved elevated whole-body protein synthesis (28 g/kg/day) and jejunal mucosal free lysine level (0.26 μmol/g tissue), outperforming free lysine and dipeptide combination groups. Reduced jejunal mucosal myeloperoxidase activity significantly relative to the two control groups. Upregulated occludin (relative expression = 2.8) and PepT1 (relative expression = 0.75) protein levels, with occludin higher than both reference groups and PepT1 higher than free lysine group only. Boosted protein synthesis rates in liver, jejunal mucosa, gastrocnemius and longissimus dorsi muscle versus dipeptide combination group, showing no statistical difference from free lysine group. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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