| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C23H33N10O17P3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
M7G (3'-OMe-5') pppA (2'-OMe) is a modified cap analog that enhances mRNA stability and translation efficiency by maintaining the correct orientation of the mRNA cap and promoting cap-dependent translation initiation, while mimicking the Cap-1 structure to reduce immunogenicity. It can be used in molecular biology research, vaccine development, and gene therapy applications[1]. It has the molecular formula C23H33N10O17P3 (MW 814.49).
Physical & Chemical Properties
| CAS Number | 3047739-39-6 |
|---|---|
| Molecular Formula | C23H33N10O17P3 |
| Molecular Weight | 814.49 g/mol |
| SMILES | NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC)[C@H](O)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=[N+]5C)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4OC)([O-])=O)(O)=O)(O)=O)O3 |
| Signaling Pathway | Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. BenchChem. An In-depth Technical Guide to M7G(3'-OMe- 5')pppA(2'-OMe): A Modified Cap Analog for Enhanced mRNA Function. BenchChem, 2026.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
During in vitro transcription reactions with phage RNA polymerase, M7G (3'-OMe-5') pppA (2'-OMe) (2 h) makes it possible to synthesize mRNA with a predominantly forward cap structure and extremely high relative translation efficiency, plus strong stability and low immunogenicity[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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