| Field | Specification |
|---|---|
| Target | |
| Alternative names | m7G(5')ppp(5')(2'OMeA)pG |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H43N15O24P4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
m7GpppAmpG, also known as m7G(5')ppp(5')(2'OMeA)pG, is a trinucleotide 5′ cap analog. It binds eIF4E with a Kd of 45.6 nM, caps RNA with 90% efficiency, and enhances mRNA stability and translation efficiency; it is used in mRNA therapeutic research[1][2][3]. It has a molecular formula of C32H43N15O24P4 and a molecular weight of 1145.66 g/mol.
Physical & Chemical Properties
| CAS Number | 62858-30-4 |
|---|---|
| Molecular Formula | C32H43N15O24P4 |
| Molecular Weight | 1145.66 g/mol |
| SMILES | NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC)[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)(O)=O)[C@@H](COP(OP(OP(OC[C@H]7O[C@@H](N(C=[N+]8C)C9=C8C(N=C(N)N9)=O)[C@H](O)[C@@H]7O)([O-])=O)(O)=O)(O)=O)O3 |
| Target | eIF4E |
| Signaling Pathway | Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
eIF4E 45.6 nM (Kd) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[2]. Zhang H, et al. GPT-Driven Generation and Biological Activity Evaluation of Novel mRNA Trinucleotide Cap1 Analogs for mRNA Vaccine or Immunotherapy. Journal of Materials Chemistry B, 2025.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
m7GpppAmpG allows efficient RNA capping, at 90% efficiency[1]. m7GpppAmpG binds eIF4E, with a KD value of 45.6 nM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
