| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C47H45FN6O17 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Mal-Gly-PAB-Exatecan-D-glucuronic acid can be used for the synthesis of antibody-drug conjugates (ADCs) and can also be used in tumor research and diagnosis[1]. It is supplied as a light yellow to green yellow solid (C47H45FN6O17, MW 984.89) at 98.98% purity.
Physical & Chemical Properties
| CAS Number | 2763252-25-9 |
|---|---|
| Molecular Formula | C47H45FN6O17 |
| Molecular Weight | 984.89 g/mol |
| Purity | 98.98% |
| Appearance | Solid |
| Color | Light yellow to green yellow |
| SMILES | O=C(C=CC1=O)N1CCC(NCC(NC(C=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=C(C=C2)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)C(O)=O)=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cell Cycle/DNA Damage |
| Bioactivity Class | Camptothecins |
| Solubility | In Vitro: DMSO: 100 mg/mL (101.53 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Anderl Jan, et al. Anti-CEACAM5 antibodies and conjugates and uses thereof. World Intellectual Property Organization, WO2022048883 A1. 2022-03-10.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (101.53 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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