| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C34H41N7O12 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. It is supplied as a white to off-white solid (C34H41N7O12, MW 739.73) at 98.41% purity.
Physical & Chemical Properties
| CAS Number | 2249935-92-8 |
|---|---|
| Molecular Formula | C34H41N7O12 |
| Molecular Weight | 739.73 g/mol |
| Purity | 98.41% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=[N+]([O-])C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCN3C(C=CC3=O)=O)=O)=O)=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Bioactivity Class | Protease Cleavable Linker, Cleavable Linker |
| Solubility | In Vitro: DMSO: 125 mg/mL (168.98 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 125 mg/mL (168.98 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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