| Field | Specification |
|---|---|
| Target | |
| Alternative names | Malonyl coenzyme A |
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite — Human Gut Microbiota Metabolites |
| Molecular weight | |
| Molecular formula | C24H38N7O19P3S |
| Activity | |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Malonyl CoA, also known as malonyl coenzyme A, is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. It is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2]. It has a molecular formula of C24H38N7O19P3S and a molecular weight of 853.58 g/mol.
Physical & Chemical Properties
| CAS Number | 524-14-1 |
|---|---|
| Molecular Formula | C24H38N7O19P3S |
| Molecular Weight | 853.58 g/mol |
| Structure Classification | Others |
| SMILES | O[C@H]1[C@](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(O)=O)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2 |
| Target | CPT-1 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Bioactivity Class | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite — Human Gut Microbiota Metabolites |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In MCF-7 cells, Malonyl CoA (20 μM, 6 min) lowers CPT1 activity by 75%[2]. In liver mitochondria from fed virgin female rats, Malonyl CoA (0-3 μM) inhibits CPT1 activity[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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ARID1A Stimulates Notch-TLL1 Signaling to Induce Cancer-Associated Fibroblast Activation and Intrahepatic Cholangiocarcinoma Development. Cancer Res 2026 Jul 17. PMID: 42466903
Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer. Nat Commun 2026 May 11;17(1):4190. PMID: 42115216
Mechanistic role of lipid metabolism in foot-and-mouth disease virus (FMDV) replication. Vet Res 2026 May 9;57(1):72. PMID: 42106845
