| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C15H10BrN3O2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MAO-B-IN-30 is a potent, selective, blood-brain-barrier-penetrant inhibitor of MAO-B, with IC50 values of 19.176 μM against MAO-A and 0.082 μM against MAO-B. It shows antiproliferative activity without cytotoxicity, lowers levels of TNF-alpha, IL-6, and NF-kB, and has been proposed as a candidate for Parkinson's disease research[1]. It is supplied as a light yellow to yellow solid (C15H10BrN3O2, MW 344.16) at 98.53% purity.
Physical & Chemical Properties
| CAS Number | 82973-15-7 |
|---|---|
| Molecular Formula | C15H10BrN3O2 |
| Molecular Weight | 344.16 g/mol |
| Purity | 98.53% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C(/C1=N\NC(C2=CC=C(Br)C=C2)=O)NC3=C1C=CC=C3 |
| Target | MAO-B, MAO-A |
| Signaling Pathway | Neuronal Signaling |
| Solubility | In Vitro: DMSO: 4.17 mg/mL (12.12 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
MAO-B 0.082 μM (IC50) |
MAO-A 19.176 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 4.17 mg/mL (12.12 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
MAO-B-IN-30 (compound IS7) (0-100 μM) displays antiproliferative activity in SH-SY5Y cells, with an IC50 value of 97.15 μM[1].
Cell Viability Assay[1]
| Cell Line | SH-SY5Y cells |
|---|---|
| Concentration | 0-100 μM |
| Incubation Time | 24 h |
| Result | Inhibited cell growth and non-cytotoxic. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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