| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C21H25N7O2 |
| Purity | |
| SMILES | |
| Form | Crystal |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MASTL-IN-2 is an inhibitor of MASTL, the microtubule-associated serine/threonine kinase-like protein. It inhibits proliferation of human epithelial MIA PaCa cancer cells with an IC50 of 2.8 nM[1]. It is supplied as a light yellow to light brown crystal (C21H25N7O2, MW 407.47) at 98.89% purity.
Physical & Chemical Properties
| CAS Number | 3024916-69-3 |
|---|---|
| Molecular Formula | C21H25N7O2 |
| Molecular Weight | 407.47 g/mol |
| Purity | 98.89% |
| Appearance | Crystal |
| Color | Light yellow to light brown |
| SMILES | O=C(OCC1)N1C(N=C2N)=CC3=C2C=NC(NC4=NC=CC(C(CC)(N)CC)=C4)=C3 |
| Signaling Pathway | Cell Cycle/DNA Damage; Cytoskeleton |
| Solubility | In Vitro: DMSO: 62.5 mg/mL (153.39 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Gallego, R. et al. 266th Am Chem Soc (ACS) Natl Meet (Aug 13-17, San Francisco) 2023, Abst 3903796
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 62.5 mg/mL (153.39 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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