| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C63H93N9O20 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
MC-betaglucuronide-MMAE-2 is an agent-linker conjugate for ADC applications with potent antitumor activity, combining the tubulin polymerization inhibitor MMAE with the cleavable ADC linker MC-betaglucuronide. It is supplied as a white to off-white solid (C63H93N9O20, MW 1296.46) at 95.00% purity.
Physical & Chemical Properties
| CAS Number | 1703778-81-7 |
|---|---|
| Molecular Formula | C63H93N9O20 |
| Molecular Weight | 1296.46 g/mol |
| Purity | 95.00% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O[C@H]1[C@H](O)[C@@H](O)[C@H](OC2=C(NC(CCNC([C@H](CN)N3C(C=CC3=O)=O)=O)=O)C=C(COC(N(C)[C@@H](C(C)C)C(N[C@H](C(N(C)[C@@H]([C@H](CC)C)[C@H](OC)CC(N4[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C5=CC=CC=C5)=O)CCC4)=O)=O)C(C)C)=O)=O)C=C2)O[C@@H]1C(O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Bioactivity Class | Auristatin |
| Solubility | In Vitro: DMSO: ≥ 100 mg/mL (77.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. The compound is unstable in solutions, freshly prepared is recommended. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | ≥ 100 mg/mL (77.13 mM) | use freshly opened DMSO (absorbed moisture lowers solubility) |
The manufacturer notes that the compound is unstable in solution; prepare solutions fresh before use.
Data provided by the manufacturer.
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